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Production Chemist

Role Summary/Purpose

This Production Chemist role has a high emphasis on custom amidite production, development of synthesis schemes for novel phosphoramidite generation, production of other reagents in support of oligo production and documentation of all of these processes.

Essential Responsibilities

  • Duties include (but are not limited to):
  • Independently generate amidites and other reagents for use in oligo production
  • Maintaining and monitoring appropriate levels of inventory for both synthetic intermediates and final products
  • Identifying, developing processes, and resolving technical challenges and difficulties
  • Developing new and custom modifications and synthesis strategies
  • Organizing work and recording all procedures accurately and consistently with notebooks and batch records.
  • Writing standard operating and quality procedures
  • Evaluating and extending new chemistries as well as providing innovations which can be developed into new product advantages

Quality Specific Goals:

  • Aware of and comply with the Horizon Discovery Quality Manual, Quality Management System, Quality Management Policy, Quality Goals, and applicable laws and regulations as they apply to this job type/position
  • Complete all planned Quality & Compliance training within the defined deadlines
  • Identify and report any quality or compliance concerns and take immediate corrective action as required
  • Support compliance/closure of Regulatory and Quality requirements before completing Design Outputs/Program Deliverables
  • Participate in continuous improvement activities by identifying and appropriately escalating process and product quality gaps, providing solutions when possible


  • Bachelor’s degree in Chemistry
  • Field with 5+ years relevant work experience

Desired Characteristics

  • Master’s degree or PhD in Chemistry
  • Experience in the synthesis of modified phosphoramidites is preferred
  • Demonstrated problem solving ability and results orientation
  • Self-starter, energizing, and able to multi-task
  • Good oral and written communication skills
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