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Scientist/Senior Scientist - CRISPR-Cas9 Screening

Horizon is the leading life science company supplying research tools to organisations engaged in genomics research and the development of personalised medicines.  The Company is a trusted supplier of genetically-defined cell lines, reporter gene assay kits, genomic reference standards and contract research services to organizations engaged in bio-pharmaceutical process optimization, drug discovery & development, and clinical diagnostic development. Horizon aspires to provide science-driven research solutions that lead to the advancement in the understanding of the genetic basis of disease and the delivery of better healthcare outcomes for patients.

We great opening for a cell biologist to work as part of our Functional Genomic Screening Team focused on providing translational research services, primarily CRISPR-Cas9 screening, to the biotech and pharma community to support drug discovery programmes throughout the pre-clinical process.

KEY RESPONSIBILITIES:

  • To design, plan and execute research projects
  • To maintain an awareness of the current techniques/technologies and apply these to experimental design
  • Report on milestone delivery and project status to Project Lead or Department Manager
  • To interpret experimental data and play a role in planning of further experiments
  • To identify and solve problems associated with their own experiments
  • Ensure all records are accurately maintained
  • To be an effective team member in supporting the research and development functions in Horizon
  • Interact widely with acknowledged experts within and outside own discipline
  • Make a major contribution to success of company

CORE SKILLS REQUIRED:

  • Experienced in mammalian cell culture with excellent aseptic technique
  • Demonstrable experience and skill in molecular biology
  • Excellent interpersonal and communication skills, both written and verbal
  • Ability to work at pace and run complex experiments along with the ability to learn new techniques and areas of biology

DESIRABLE SKILLS:

  • Experience of pooled functional genomic screening e.g. CRISPR-Cas9, shRNA etc
  • Resistance and Sensitivity screening with compounds
  • Safe handling and production of lentiviral reagents
  • Experience of handling large datasets including with NGS data
  • Experience of flow cytometry analysis and sorting
  • Experience in assay development

Ideally you will be qualified with a PhD and as least 1 year's experience. This is a lab-based role and candidates should be highly self-motivated, able to work to tight timelines and be comfortable working with shifting priorities.  Excellent communication skills, a careful and meticulous nature and attention to detail are essential.

 

We can offer a varied, fast paced and interesting working environment and as a growing company we are focused on recognition and empowerment of our employees.  We are committed to high quality science to meet our client and growth needs.  In addition to competitive salaries we can offer an attractive flexible benefits package.

In return we offer a varied and interesting working environment and we are focused on recognition and empowerment of our scientists and operational teams and a competitive salary and benefits package, including:

Group Personal Pension Plan with enhanced company contribution
Medical, Health & Life Insurances
Employee share purchase plan (Sharesave) 
25 days annual leave
One paid working day each year for volunteering
Childcare vouchers

 

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